Slaughterhouse -Five is a novel by Kurt Vonnegut, considered to be one of the most popular writers of American Literature of the Twentieth century. The paper is an attempt to analyse destructiveness of war which includes description about the destructive effects of war, both physical and mental. It shows how, the soldiers who are trained to withstand all horrors of war are forced to pay the price in their post war life. It gives special attention to the mental health of the war veterans and how they device various plans to escape from the excruciating experiences and memories of the war. The present study is an attempt to focus destructiveness of war which exemplifies not only how far war can affect the world physically but also the drastic changed it brings about on the mentality of these who gets involved in the war.